D-cloprostenol (PGF2a Super-Agonist) Catalog Description 50mcg/ml, 60ml
D-cloprostenol or (+)-cloprostenol sodium is a strong PGF2a analog or FP receptor agonist. Similar to latanoprost, bimatoprost, and native PGF2a, it binds to the prostaglandin FP receptor, except with orders of magnitude greater affinity. Cotsarelis and Garza baldness studies have resulted in an increased interest in the compounds known as prostaglandins; PGD2 has been shown to be involved in baldness, specifically androgenic alopecia (AA), while other prostaglandins have demonstrated opposite effects. PGF2a and its analogs (d-cloprostenol, latanoprost, bimatoprost) have shown local hair-growth effects in early androgenic alopecia trials and are acknowledged by FDA approval to induce growth of certain hairs, such as eyelashes.
Synthetic agonists of the FP receptor such as d-cloprostenol and other analogs of PGF2a exhibit a hair growth effect through the FP receptor, but secondary effects may come through inhibition or reduction of prostaglandin D2 (PGD2). Local physiological production or function of prostaglandins may be involved in the differentiation and control of hair growth according to Colombe et al.
PGE2 and analogs were initially found to grow hair, but later results were not replicated; PGE2 failed to bind to the prostaglandin FP receptor.
D-cloprostenol is many times more potent than bimatoprost or latanoprost (Latisse, Lumigan), used at 50-100mcg/ml to induce hair growth, and is considered a super-agonist.
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 Kevin J. McElwee, PhD and Jerry Shapiro, MD, FRCPC. Promising Therapies for Treating and/or Preventing Androgenic Alopecia. Skin ther. Let.