D-Cloprostenol 50mcg / ml, 60ml

D-Cloprostenol 50mcg / ml, 60ml

Brand: Full Catalog
Product Code: DC30
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Price: $62.00
Description

D-cloprostenol (PGF2a Super-Agonist) Catalog Description 50mcg/ml, 60ml

D-cloprostenol or (+)-cloprostenol sodium is a strong PGF2a analog or FP receptor agonist.  Similar to latanoprost, bimatoprost, and native PGF2a, it binds to the prostaglandin FP receptor, except with orders of magnitude greater affinity. Cotsarelis and Garza baldness studies have resulted in an increased interest in the compounds known as prostaglandins; PGD2 has been shown to be involved in baldness, specifically androgenic alopecia (AA), while other prostaglandins have demonstrated opposite effects[1]. PGF2a and its analogs (d-cloprostenol, latanoprost, bimatoprost) have shown local hair-growth effects in early androgenic alopecia trials and are acknowledged by FDA approval to induce growth of certain hairs, such as eyelashes[2][3][4][5][6].

Synthetic agonists of the FP receptor such as d-cloprostenol and other analogs of PGF2a exhibit a hair growth effect through the FP receptor, but secondary effects may come through inhibition or reduction of prostaglandin D2 (PGD2). Local physiological production or function of prostaglandins may be involved in the differentiation and control of hair growth according to Colombe et al[7].

PGE2 and analogs were initially found to grow hair, but later results were not replicated; PGE2 failed to bind to the prostaglandin FP receptor[7][8].

D-cloprostenol is many times more potent than bimatoprost or latanoprost (Latisse, Lumigan), used at 50-100mcg/ml to induce hair growth, and is considered a super-agonist[9].

Citations

[1] Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med. 2012 Mar 21;4(126):126ra34.

[2]Wolf R, Matz H, Zalish M, Pollack A, Orion E. Prostaglandin analogs for hair growth: Great expectations. Dermatology Online Journal 9(3): 7

[3]Uno H, Zimbric ML, Albert DM, Stjernschantz J. Effect of latanoprost on hair growth in the bald scalp of the stump-tailed macacque: a pilot study. Acta Derm Venereol. 2002;82(1):7-12.

[4] Blume-Peytavi U, Lönnfors S, Hillmann K, Garcia Bartels N. A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia. J Am Acad Dermatol. 2012 May;66(5):794-800.

[5] Johnstone MA, Albert DM. Prostaglandin-induced hair growth. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S185-202.

[6] Sasaki S, Hozumi Y, Kondo S. Influence of prostaglandin F2alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model. Exp Dermatol. 2005 May;14(5):323-8.

[7] Colombe L et al. Prostaglandin metabolism in human hair follicle. Exp Derm. Vol 16, 9, p762–9, Sept 2007.

[8] Griffin BW, Magnino PE, Pang IH, Sharif NA. Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization. J Pharmacol Exp Ther. 1998 Jul;286(1):411-8.

[9] Kevin J. McElwee, PhD and Jerry Shapiro, MD, FRCPC. Promising Therapies for Treating and/or Preventing Androgenic Alopecia. Skin ther. Let.

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