Hexarelin, 2000mcg

Hexarelin, 2000mcg

Brand: Full Catalog
Product Code: HX02
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Price: $48.00
Description

Hexarelin Information

Hexarelin, sometimes called examorelin, is a potent growth hormone secretagogue (GHS) hexapeptide. As a member of the synthetic class of secretagogues known as growth-hormone secretagogue peptides (GHRPs), hexarelin primarily exerts its action at the pituitary level by acting as a ghrelin mimetic[1]. According to published literature hexarelin powerfully inhibits somatostatin, recruits or activates somatotrophs (GH-producing pituitary cells), and increases appetite in mammals. Compared to growth-hormone releasing hormone (GHRH) analogs such as Modified GRF (1-29), ghrelin mimetics are more robust and less susceptible to environmental and physiological factors that degrade the peptide or inhibit the release of growth hormone[1].

Although GHRPs and GHRH analogs combined are synergistic, relatively speaking GHRPs have been demonstrated in a controlled environment to release  a greater amount of growth hormone[2]. Hexarelin, along with GHRP-2, GHRP-6, and ipamorelin, is among the most-studied secretagogue peptides. Of that group of four GHRPs, ipamorelin has the least GH-releasing efficacy and the least release of cortisol and prolactin, while hexarelin induces the most potent GH release along with higher levels of cortisol and prolactin[3].

Like other GHRPs, hexarelin also has unique properties that are not directly tied to the release of growth hormone from the pituitary.  Hexarelin "reduces injury of cerebral cortex and hippocampus after brain hypoxia-ischemia in neonatal rats" according to Liu et al (2006), an effect that may overlap with full-chain ghrelin[4].  A possible shared effect of multiple GHRPs is an antioxidant benefit on the testis through a receptor called GHS-R type 1a, present in Sertoli and Leydig cells; reduction of lipid peroxidation and increasing the activity of the body's three main antioxidant systems may additionally protect spermatozoa from free radicals. [5]

Finding of Pang et al suggested hexarelin holds promise of possible clinical development and use in treating atherosclerosis (2009):

Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats. Hexarelin also decreased [(3)H]-TdR incorporation in cultured vascular smooth muscle cell (VSMC) and calcium sedimentation in aortic wall. Furthermore, foam cell formation induced by ox-LDL was decreased by hexarelin. In conclusion, hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in rats, possibly through up regulating HDL-c/LDL-c ratio, vascular NO production and downregulating the VSMC proliferation, aortic calcium sedimentation and foam cell formation. These novel anti-atherosclerotic actions of hexarelin suggest that the peptide might have a clinical potential in treating atherosclerosis. [7]

According to Bresciani et al (2008) "hexarelin is endowed with long-lasting orexigenic activity and might represent a potential therapeutic approach for pathological conditions characterized by a decline in food intake." [8]

Citations
[1]Penalva, A., Carballo, A., Pombo, M., Casanueva, F.F. and Dieguez, C. (1993) Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine or hypoglycemia on GHRP- 6-induced GH secretion in man. J. Clin. Endocrinol. Metab. 76, 168–171
[2]Bowers CY, Reynolds GA, Chang D, Hong A, Chang K, Momany F. A study on the regulation of GH release from the pituitary of rats, in vitro. Endocrinology 1981;108(3):1070–1079.
[3]Ghigo, E., Arvat, E., Muccioli, G. and Camanni, F. (1997) Growth hormone releasing peptides. Eur. J. Endocrinol. 136, 445–460
[4]Liu Y, Wang PS, Xie D, Liu K, Chen L. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin J Physiol. 2006 Oct 31;49(5):244-50.
[5]Kheradmand. Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia, Nov 2008, Volume 41, Issue 6, Pages 335-340
[6]Pang JJ, Xu RK, Xu XB, Cao JM, Ni C, Zhu WL, Asotra K, Chen MC, Chen C.  Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro.  Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1063-9. Epub 2003 Nov 13.
[7]Pang J, Xu Q, Xu X, Yin H, Xu R, Guo S, Hao W, Wang L, Chen C, Cao JM.  Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat.  Peptides. 2010 Apr;31(4):630-8. Epub 2009 Nov 30.
[8] Bresciani E, Pitsikas N, Tamiazzo L, Luoni M, Bulgarelli I, Cocchi D, Locatelli V, Torsello A. Feeding behavior during long-term hexarelin administration in young and old rats.  J Endocrinol Invest. 2008 Jul;31(7):647-52.

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